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      Recombinant Human Atypical chemokine receptor 2(ACKR2) (Active)

      • 貨號:
        CSB-CF004618HU
      • 規格:
        ¥21114
      • 圖片:
        • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

      • 其他:

      產品詳情

      • 純度:
        Greater than 85% as determined by SDS-PAGE.
      • 生物活性:
        Measured by its binding ability in a functional ELISA. Immobilized ACKR2 at 1 μg/ml can bind human CCL2, the EC50 of human CCL2 protein is 23.52-30.99 μg/ml.
      • 基因名:
        ACKR2
      • Uniprot No.:
      • 別名:
        C C chemokine receptor D6; C-C chemokine receptor D6; CC chemokine binding receptor JAB61; CC chemokine receptor D6; CCBP 2; CCBP2; CCBP2_HUMAN; CCR 10; CCR 9; CCR10; CCR9; Chemokine (C C motif) receptor 9; Chemokine (C C) receptor 9; Chemokine binding protein 2; Chemokine binding protein D6; Chemokine C C motif receptor 9; Chemokine C C receptor 9; Chemokine CC motif receptor 9; Chemokine CC receptor 9; Chemokine receptor 9; Chemokine receptor CCR 10; Chemokine receptor CCR 9; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine receptor CCR10; Chemokine receptor CCR9; Chemokine receptor D6; Chemokine-binding protein 2; Chemokine-binding protein D6; CMKBR 9; CMKBR9; D6; hD6; MGC126678; MGC138250
      • 種屬:
        Homo sapiens (Human)
      • 蛋白長度:
        Full Length
      • 來源:
        in vitro E.coli expression system
      • 分子量:
        46.9 kDa
      • 表達區域:
        1-384aa
      • 氨基酸序列
        MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA
      • 蛋白標簽:
        N-terminal 10xHis-tagged
      • 產品提供形式:
        Liquid or Lyophilized powder
        Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
      • 緩沖液:
        Tris-based buffer,50% glycerol
      • 儲存條件:
        Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
      • 保質期:
        The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
        Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
      • 貨期:
        Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
        Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
      • 注意事項:
        Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
      • Datasheet & COA:
        Please contact us to get it.

      靶點詳情

      • 功能:
        Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
      • 基因功能參考文獻:
        1. Data suggest that MIRN146b and MIR10b directly bind 3'-untranslated region of ACKR2 and down-regulate expression of ACKR2 in keratinocytes and in lymphatic endothelial cells, respectively. (ACKR2 = atypical chemokine receptor 2) PMID: 29279330
        2. ACKR2 is induced after traumatic brain injuries and has a significant impact on mortality and lesion development acutely following closed head injury. PMID: 29176798
        3. ACKR2 is a molecular regulator play a role in inflammatory changes in patients with psoriasis. PMID: 28010760
        4. Data indicates that D6 is concentrated on trophoblast cell membranes in pre-eclampsia, in line with higher circulating levels of D6-ligand chemokines, but its scavenging activity is affected by trophoblast cytoskeleton disarrangement. PMID: 27780270
        5. ACKR2 mediates chemokine scavenging by primary human trophoblasts. PMID: 25297873
        6. Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance. PMID: 24644289
        7. Data show that low decoy receptor D6 expression correlated to more invasive tumors and that tumor location influences D6 expression, which is lower in the more distal parts of the colon. PMID: 24013383
        8. engagement of the ACR D6 by its ligands activates a beta-arrestin1-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin through the Rac1-PAK1-LIMK1 cascade. PMID: 23633677
        9. co-expression of DARC, D6, and CCX-CKR significantly associated with higher survival in gastric cancer PMID: 23462454
        10. D6, which is upregulated in both inflammatory and tumor contexts, is an essential regulator of inflammatory leukocyte interactions with lymphatic endothelial cells(LECs) and is required for immature/mature DC discrimination by LECs. PMID: 23479571
        11. We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response. PMID: 22939232
        12. CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy. PMID: 22226505
        13. D6 is expressed in AMs from patients with COPD, and its expression correlates with the degree of functional impairment and markers of immune activation. PMID: 22797410
        14. These data demonstrate a novel role for D6 as a regulator of the transition from uninvolved to lesional skin in psoriasis. PMID: 22867710
        15. Chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction. PMID: 22796582
        16. DARC and D6, the most studied members of this group of molecules, are reviewed. PMID: 21151196
        17. Chemokne D6 expression is higher in biopsies taken from more severe cardiac allograft rejection. PMID: 20404785
        18. D6 protein is found predominantly inside human choriocarcinoma-derived cells with only a small fraction available on the cell surface at any one time, yet it can progressively remove extracellular chemokines, without apparent desensitization. PMID: 20147628
        19. CCR10 is unlikely to be necessary for cutaneous homing of TH cells in the models studied here. CCR10 may instead play a role in the movement of specialized "effector" cutaneous TH cells to and/or within epidermal microenvironments. PMID: 12406880
        20. In lymphatic vessels D6 acts as a nonsignaling decoy receptor and scavenger for inflammatory CC chemokines, by clearing them and preventing excessive diffusion via afferent lymphatics to lymph nodes. PMID: 12594248
        21. CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts PMID: 12671049
        22. D6 is constitutively internalized via a ligand-independent, phosphorylation-independent association with beta-arrestin. PMID: 15084596
        23. We also propose that lymphatic endothelial cell-expressed D6 might have a distinct but complementary role in restricting inflammatory leukocyte access to the lymphatic vasculature. PMID: 16814608
        24. demonstrate the importance of proinflammatory CC chemokines in de novo tumorigenesis and reveal chemokine sequestration by D6 to be a novel and effective method of tumor suppression PMID: 17607362
        25. the heptahelical body of D6 on its own can engage the endocytotic machinery of HEK293 cells but that the C terminus is indispensable for scavenging because it prevents initial chemokine engagement of D6 from inhibiting subsequent chemokine uptake. PMID: 18201974
        26. Emphasis on two new players involved in regulating inflammation at the maternal-fetal interface: the long pentraxin PTX3 and the decoy receptor for inflammatory chemokines D6. PMID: 18676013
        27. D6 plays a negative role in the growth and metastasis of breast cancer. PMID: 18708360
        28. D6 expression is GATA1 dependent PMID: 18714007
        29. Genetic variations are associated with liver inflammation in chronic hepatitis C PMID: 18822328
        30. Immunohistochemistry on lung lymph nodes from patients with pulmonary tuberculosis showed that D6 expression was prominent in lymphatic endothelial cells, while CD68-positive macrophages did not stain for D6. PMID: 19446728
        31. D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987

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      • 亞細胞定位:
        Early endosome, Recycling endosome, Cell membrane, Multi-pass membrane protein
      • 蛋白家族:
        G-protein coupled receptor 1 family, Atypical chemokine receptor subfamily
      • 組織特異性:
        Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Als
      • 數據庫鏈接:

        HGNC: 1565

        OMIM: 602648

        KEGG: hsa:1238

        STRING: 9606.ENSP00000273145

        UniGene: Hs.146346



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