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      Recombinant Human SIN3-HDAC complex-associated factor(SINHCAF) (Active)

      • 貨號:
        CSB-EP882059HUe0
      • 規格:
        ¥14796
      • 圖片:
        • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
        • Activity
          Measured by its binding ability in a functional ELISA. Immobilized LCN2 at 2 μg/ml can bind human SINHCAF, the EC50 of human SINHCAF protein is 31.54-38.59 μg/ml.
      • 其他:

      產品詳情

      • 純度:
        Greater than 85% as determined by SDS-PAGE.
      • 生物活性:
        Measured by its binding ability in a functional ELISA. Immobilized LCN2 at 2 μg/ml can bind human SINHCAF, the EC50 of human SINHCAF protein is 31.54-38.59 μg/ml.
      • 基因名:
        SINHCAF
      • Uniprot No.:
      • 別名:
        SINHCAF; C12orf14; FAM60A; L4; SIN3-HDAC complex-associated factor; Protein FAM60A; Tera protein homolog
      • 種屬:
        Homo sapiens (Human)
      • 蛋白長度:
        Full Length
      • 來源:
        E.coli
      • 分子量:
        51.9 kDa
      • 表達區域:
        1-221aa
      • 氨基酸序列
        MFGFHKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQSCFGLHETRSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKVKTLSGNRIKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDDGSDTEMASGSNRTPVFSFLDLTYWKRQKICCGIIYKGRFGEVLIDTHLFKPCCSNKKAAAEKPEEQGPEPLPISTQEW
      • 蛋白標簽:
        N-terminal GST-tagged
      • 產品提供形式:
        Liquid or Lyophilized powder
        Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
      • 緩沖液:
        Tris-based buffer,50% glycerol
      • 儲存條件:
        Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
      • 保質期:
        The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
        Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
      • 貨期:
        Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
        Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
      • 注意事項:
        Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
      • Datasheet & COA:
        Please contact us to get it.

      靶點詳情

      • 功能:
        Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway
      • 基因功能參考文獻:
        1. FAM60A may act as a key transcriptional factor to regulate genes that are correlated with each cell cycle of tumor cells in esophageal cancer. PMID: 28169357
        2. studies reveal that loss of FAM60A or another component of the Sin3 complex, SDS3, leads to a change in cell morphology and an increase in cell migration PMID: 22984288
        3. Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex. PMID: 22865885
      • 亞細胞定位:
        Nucleus
      • 蛋白家族:
        SINHCAF family
      • 數據庫鏈接:

        HGNC: 30702

        OMIM: 615027

        KEGG: hsa:58516

        STRING: 9606.ENSP00000337477

        UniGene: Hs.505154



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