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      Recombinant Rat RAC-gamma serine/threonine-protein kinase(Akt3)

      • 貨號:
        CSB-YP723581RA
      • 規格:
      • 來源:
        Yeast
      • 其他:
      • 貨號:
        CSB-EP723581RA
      • 規格:
      • 來源:
        E.coli
      • 其他:
      • 貨號:
        CSB-BP723581RA
      • 規格:
      • 來源:
        Baculovirus
      • 其他:
      • 貨號:
        CSB-MP723581RA
      • 規格:
      • 來源:
        Mammalian cell
      • 其他:

      產品詳情

      • 純度:
        >>85% (SDS-PAGE)
      • 基因名:
        Akt3
      • Uniprot No.:
      • 別名:
        Akt3RAC-gamma serine/threonine-protein kinase; EC 2.7.11.1; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma
      • 種屬:
        Rattus norvegicus (Rat)
      • 蛋白長度:
        Full Length of Mature Protein
      • 氨基酸序列
        SDVTIVKED WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDPKEIM RHSFFSGVNW QDVYDKKLVP PFKPQVTSET DTRYFDEEFT AQTITITPPE KDDDDGMDCM DNERRPHFPQ FSYSASGRE
      • 蛋白標簽:
        The following tags are available.
        N-terminal His-tagged
        Tag-Free
        The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
      • 產品提供形式:
        Lyophilized powder
      • 復溶:
        We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
      • 儲存條件:
        Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
      • 保質期:
        The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
        Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
      • 貨期:
        Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
        Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
      • 注意事項:
        Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
      • Datasheet :
        Please contact us to get it.

      靶點詳情

      • 功能:
        AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis (By similarity).
      • 基因功能參考文獻:
        1. Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis PMID: 11907032
      • 亞細胞定位:
        Nucleus, Cytoplasm, Membrane, Peripheral membrane protein
      • 蛋白家族:
        Protein kinase superfamily, AGC Ser/Thr protein kinase family, RAC subfamily
      • 數據庫鏈接:


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