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      免疫檢查點

      Immune Checkpoints

      免疫檢查點是免疫激活的調控因子,主要在免疫應答過程中調節T細胞受體(TCR)的抗原識別。它們在維持免疫穩態和預防自身免疫方面至關重要。根據不同的免疫激活作用,免疫檢查點可分為兩種類型:共刺激免疫檢查點和共抑制免疫檢查點。共刺激免疫檢查點是指一系列可以進一步刺激免疫反應的免疫檢查點,如CD28,ICOS和CD137。相反,共抑制免疫檢查點對抑制免疫反應的免疫檢查點,如PD1,CTLA-4和VISTA。在有效的抗腫瘤免疫過程中,T細胞作為核心的執行者,首先被T細胞受體介導的抗原識別信號激活,同時眾多的共刺激信號和共抑制信號精細調節T細胞反應的強度和質量。在生理情況下,共刺激分子與免疫檢查點分子保持平衡,從而最大程度減少對于周圍正常組織的損傷,維持對自身組織的耐受、避免自身免疫反應。而腫瘤細胞可以通過此機制,異常上調共抑制分子及其相關配體,抑制T細胞激活,從而逃避免疫殺傷。

      免疫檢查點產品

      近幾年, CUSABIO研發團隊致力于靶向免疫研究,為廣大科研用戶開發了一系列免疫檢查點重組蛋白。這些重組免疫檢查點蛋白涵蓋多種物種和標簽,秉承客戶至上的原則,所有蛋白產品在發貨前我們都會對其生物活性進行再次分析和驗證。另外,我們還提供蛋白質定制服務,如果您找不到您需要的蛋白質,請聯系我們進行定制服務。

      產品名稱 貨號 規格
      Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4(CTLA4),partial (Active) CSB-AP005121GU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) CSB-AP005131HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) CSB-AP005141HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9),partial (Active) CSB-AP005151HU 1mg/500μg/50μg/10μg
      Recombinant Human T-lymphocyte activation antigen CD86(CD86),partial (Active) CSB-AP005161HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) CSB-AP005171HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40),partial (Active) CSB-AP005181HU 1mg/500μg/50μg/10μg
      Recombinant Human CD40 ligand(CD40LG),partial (Active) CSB-AP005191HU 1mg/500μg/50μg/10μg
      Recombinant Human Leukocyte surface antigen CD47(CD47),partial (Active) CSB-AP005201HU 1mg/500μg/50μg/10μg
      Recombinant Human Leukocyte surface antigen CD47(CD47),partial (Active) CSB-AP005211HU 1mg/500μg/50μg/10μg
      Recombinant Human CD160 antigen(CD160) (Active) CSB-AP005221HU 1mg/500μg/50μg/10μg
      Recombinant Human Cytotoxic T-lymphocyte protein 4(CTLA4),partial (Active) CSB-AP005231HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 4(TNFRSF4),partial (Active) CSB-AP005241HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor receptor superfamily member 4(TNFRSF4),partial (Active) CSB-AP005251HU 1mg/500μg/50μg/10μg
      Recombinant Human Tumor necrosis factor ligand superfamily member 4(TNFSF4),partial (Active) CSB-AP005261HU 1mg/500μg/50μg/10μg
      Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1(SIRPA),partial (Active) CSB-AP005271HU 1mg/500μg/50μg/10μg
      Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial (Active) CSB-AP005281HU 1mg/500μg/50μg/10μg
      Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial (Active) CSB-AP005291HU 1mg/500μg/50μg/10μg
      Recombinant Mouse Cytotoxic T-lymphocyte protein 4(Ctla4),partial (Active) CSB-AP005301MO 1mg/500μg/50μg/10μg
      Recombinant Mouse Tumor necrosis factor receptor superfamily member 14(Tnfrsf14),partial (Active) CSB-AP005311MO 1mg/500μg/50μg/10μg


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