流行SARS-CoV-2變異株產品大合集

瀏覽次數:237      日期:2021-08-25 16:14:47

2019年底爆發的COVID19疫情仍在全球肆虐。SARS-CoV-2,作為這種流行病的起因,突變速度令人瞠目結舌。SARS-CoV-2僅用了一年多的時間,從 Alpha 發展到 Lambda,讓WHO用了將近 1/2 的希臘字母來為其變異株命名。2020年12月末,在英國發現SARS-CoV-2變異株Alpha,至此,英國疫情失控。緊接著,在南非發現了變異株Beta,在印度發現了變異株Delta,在秘魯發現了變異株Lambda。

針對全球SARS-CoV-2的主要變種,華美生物可提供多種標簽的優質突變抗原。絕大多數突變抗原已驗證生物活性。

>>SARS-CoV-2 Lambda | C.37 (南美突變株)

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (R203K,G204R) (Active) CSB-EP3325GMY(M12) E.coli R203K, G204R N-terminal 6xHis-tagged

>>SARS-CoV-2 Delta | B.1.617.2 (印度突變株)

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (D63G,R203M,D377Y) (Active) CSB-EP3325GMY(M14) E.coli D63G, R203M, D377Y N-terminal 6xHis-tagged

>>SARS-CoV-2 Kappa | B.1.617.1 (印度突變株)

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (R203M,D377Y) (Active) CSB-EP3325GMY(M13) E.coli R203M, D377Y N-terminal 6xHis-tagged

>>SARS-CoV-2 Alpha | B.1.1.7 (英國突變株)

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (D3L,R203K,G204R,S235F) (Active) CSB-EP3325GMY(M1) E.coli D3L, R203K, G204R, S235F N-terminal 6xHis-tagged
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (R203K,G204R) (Active) CSB-EP3325GMY(M12) E.coli R203K, G204R N-terminal 6xHis-tagged
S1 Recombinant Human Novel Coronavirus Spike glycoprotein (S) (D614G),partial (Active) CSB-MP3324GMY(M1) Mammalian cell D614G C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (N501Y),partial (Active) CSB-MP3324GMY1(M6) Mammalian cell N501Y C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (N501Y),partial (Active) CSB-MP3324GMY1(M6)k2 Mammalian cell N501Y C-terminal 6xHis-mFC-tagged

>>SARS-CoV-2 Beta | B.1.351 (南非突變株)

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (T205I) (Active) CSB-EP3325GMY(M2) E.coli T205I N-terminal 6xHis-tagged
S1 Recombinant Human Novel Coronavirus Spike glycoprotein (S) (D614G), partial (Active) CSB-MP3324GMY(M1) Mammalian cell D614G C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (N501Y), partial (Active) CSB-MP3324GMY1(M6) Mammalian cell N501Y C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (N501Y), partial (Active) CSB-MP3324GMY1(M6)k2 Mammalian cell N501Y C-terminal 6xHis-mFC-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (K417N), partial CSB-MP3324GMY1(M7) Mammalian cell K417N C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (K417N), partial CSB-MP3324GMY1(M7)h8 Mammalian cell K417N C-terminal mFC-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (E484K), partial CSB-MP3324GMY1(M8) Mammalian cell E484K C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (E484K), partial (Active) CSB-MP3324GMY1(M8)h8 Mammalian cell E484K C-terminal mFC-tagged

>>SARS-CoV-2 Gamma | P.1 (巴西突變株)

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (P80R) (Active) CSB-EP3325GMY(M3) E.coli P80R N-terminal 6xHis-tagged
S1 Recombinant Human Novel Coronavirus Spike glycoprotein (S) (D614G),partial (Active) CSB-MP3324GMY(M1) Mammalian cell D614G C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (N501Y),partial (Active) CSB-MP3324GMY1(M6) Mammalian cell N501Y C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (N501Y),partial (Active) CSB-MP3324GMY1(M6)k2 Mammalian cell N501Y C-terminal 6xHis-mFC-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein(S)(E484K),partial CSB-MP3324GMY1(M8) Mammalian cell E484K C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein(S) (E484K), partial (Active) CSB-MP3324GMY1(M8)h8 Mammalian cell E484K C-terminal mFC-tagged

>>其他SARS-CoV-2 突變株

Target Product Name Code Source Mutation Tag Info
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (P13L) (Active) CSB-EP3325GMY(M4) E.coli P13L N-terminal 6xHis-tagged
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (D103Y) (Active) CSB-EP3325GMY(M5) E.coli D103Y N-terminal 6xHis-tagged
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (L230F) (Active) CSB-EP3325GMY(M9) E.coli L230F N-terminal 6xHis-tagged
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (I292T) (Active) CSB-EP3325GMY(M10) E.coli I292T N-terminal 6xHis-tagged
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (Q384H) (Active) CSB-EP3325GMY(M11) E.coli Q384H N-terminal 6xHis-tagged
N Recombinant Human Novel Coronavirus Nucleoprotein (N) (S202N) (Active) CSB-EP3325GMY(M8) E.coli S202N N-terminal 6xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (V367F),partial (Active) CSB-MP3324GMY1(M1) Mammalian cell V367F C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (W436R), partial (Active) CSB-MP3324GMY1(M2) Mammalian cell W436R C-terminal 10xHis-tagged
S1-RBD Recombinant Human Novel Coronavirus Spike glycoprotein (S) (G476S), partial (Active) CSB-MP3324GMY1(M4) Mammalian cell G476S C-terminal 10xHis-tagged

>>部分驗證數據

● Recombinant Human Novel Coronavirus Nucleoprotein (N)(R203K,G204R) (Active) (CSB-EP3325GMY(M12))

Its purity is greater than 96% as determined by SDS-PAGE.
Its binding ability measured by functional ELISA with N Mouse Monoclonal Antibody at 2 μg/ml, of which EC50 is 6.775-13.04 ng/ml.
Its binding ability measured by functional ELISA with N Recombinant Antibody at 2 μg/ml, of which EC50 is 4.664-8.256 ng/ml.

● Recombinant Human Novel Coronavirus Nucleoprotein (N)(D63G,R203M,D377Y) (Active) (CSB-EP3325GMY(M14))

Its purity is greater than 85.7% as determined by SDS-PAGE.
Its binding ability measured by functional ELISA with N Mouse Monoclonal Antibody at 2 μg/ml, of which EC50 is 3.834 - 5.294 ng/ml.
Its binding ability measured by functional ELISA with N Recombinant Antibody at 2 μg/ml, of which EC50 is 1.304 - 1.875 ng/ml ng/ml.

● Recombinant Human Novel Coronavirus Spike glycoprotein(S) (E484K), partial (Active) (CSB-MP3324GMY1(M8)h8)

Its purity is greater than 90% as determined by SDS-PAGE.
Its binding ability measured by functional ELISA with human ACE2 at 2 μg/ml, the EC50 is 6.597-8.187 ng/ml.
Its binding ability measured by functional ELISA with Biotin-S Antibody at 2 μg/ml, the EC50 is 118.7 ng/ml.

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