AKT1S1 (AKT1 Substrate 1) is a Protein Coding gene. Diseases associated with AKT1S1 include Localized Pulmonary Fibrosis and Breast Papillomatosis. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..
CUSABIO produces high-quality anti-AKT1S1 antibodies (includes polyclonal antibodies, monoclonal antibodies, recombinant antibodies) in house with strict quality control. And they can help you discover more in your research.
These AKT1S1 antibodies are validated in multiple tissues with various applications and covering a broad range of life science research and drug development. They are featured with high specificity, multiple epitopes recognition, and wide species reactivity. Moreover, CUSABIO provides various options on sizes, excellent technical support and AKT1S1 antibodies custom service.
AKT1S1 Antibodies Catalog
|CSB-PA836185DSR2HU||AKT1S1 Antibody||Human||ELISA, IHC|
|CSB-PA836185LA01HU||AKT1S1 Antibody||Human, Rat||ELISA, WB, IHC|
|CSB-PA836185LB01HU||AKT1S1 Antibody, HRP conjugated||Human||ELISA|
|CSB-PA836185LC01HU||AKT1S1 Antibody, FITC conjugated||Human||ELISA|
|CSB-PA836185LD01HU||AKT1S1 Antibody, Biotin conjugated||Human||ELISA|
Proline-rich AKT1 substrate 1 is a protein in humans that is encoded by the AKT1S1 gene. AKT1S1 is a subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).