ATG3 Antibodies

ATG3 (Autophagy Related 3) is a Protein Coding gene. Diseases associated with ATG3 include Granulomatous Amebic Encephalitis. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin-like protein transferase activity.

CUSABIO produces high-quality anti-ATG3 antibodies (includes polyclonal antibodies, monoclonal antibodies, recombinant antibodies) in house with strict quality control. And they can help you discover more in your research.
These ATG3 antibodies are validated in multiple tissues with various applications and covering a broad range of life science research and drug development. They are featured with high specificity, multiple epitopes recognition, and wide species reactivity. Moreover, CUSABIO provides various options on sizes, excellent technical support and ATG3 antibodies custom service.

ATG3 Antibodies Catalog

ATG3 Antibodies for Homo sapiens (Human)

ATG3 Background

Ubiquitin-like-conjugating enzyme ATG3 is a protein in humans that is encoded by the ATG3 gene. The ATG3 protein is an E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2, or MAP1LC3A). The ATG12-ATG5 conjugate plays the role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and the cytoplasm to vacuole transport (Cvt). Its preferred substrate is MAP1LC3A. It also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, and ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy.



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