ATG4A (Autophagy Related 4A Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4B.
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ATG4A Antibodies Catalog
Cysteine protease ATG4A is a protein in humans that is encoded by the ATG4A gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Its preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. It has also activity of the delipidating enzyme for the PE-conjugated forms.