ATG4A Proteins

ATG4A (Autophagy Related 4A Cysteine Peptidase) is a Protein Coding gene. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4B.

The following recombinant ATG4A proteins are manufactured in house under a complete QC system by CUSABIO. They are expressed by Yeast, E.coli, Baculovirus, Mammalian cell, In Vivo Biotinylation in E.coli. Highlights of these recombinant ATG4A proteins as follow:
High purity, Low endotoxin, Multiple Tags, Animal-free, Wide applications (Cell assay, Protein-protein interaction, Drug-related studies, Enzymatic activity in vitro, Protein structure analysis, etc.)
In addition, various options on sizes, excellent technical support, and recombinant ATG4A proteins custom service will be also offered.

ATG4A Proteins Catalog

ATG4A Proteins for Oryza sativa subsp. indica (Rice)

ATG4A Proteins for Pongo abelii (Sumatran orangutan)

ATG4A Proteins for Gallus gallus (Chicken)

ATG4A Proteins for Bos taurus (Bovine)

ATG4A Proteins for Xenopus laevis (African clawed frog)

ATG4A Proteins for Oryza sativa subsp. japonica (Rice)

ATG4A Proteins for Mus musculus (Mouse)

ATG4A Proteins for Arabidopsis thaliana (Mouse-ear cress)

ATG4A Proteins for Homo sapiens (Human)

ATG4A Background

Cysteine protease ATG4A is a protein in humans that is encoded by the ATG4A gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Its preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. It has also activity of the delipidating enzyme for the PE-conjugated forms.



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