ATG4C Proteins

ATG4C (Autophagy Related 4C Cysteine Peptidase) is a Protein Coding gene. Diseases associated with ATG4C include Rem Sleep Behavior Disorder and Childhood Disintegrative Disease. Among its related pathways are Autophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is ATG4D.

The following recombinant ATG4C proteins are manufactured in house under a complete QC system by CUSABIO. They are expressed by Yeast, E.coli, Baculovirus, Mammalian cell, In Vivo Biotinylation in E.coli. Highlights of these recombinant ATG4C proteins as follow:
High purity, Low endotoxin, Multiple Tags, Animal-free, Wide applications (Cell assay, Protein-protein interaction, Drug-related studies, Enzymatic activity in vitro, Protein structure analysis, etc.)
In addition, various options on sizes, excellent technical support, and recombinant ATG4C proteins custom service will be also offered.

ATG4C Proteins Catalog

ATG4C Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

ATG4C Proteins for Xenopus laevis (African clawed frog)

ATG4C Proteins for Mus musculus (Mouse)

ATG4C Proteins for Homo sapiens (Human)

ATG4C Background

Cysteine protease ATG4C is a protein in humans that is encoded by the ATG4C gene. Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. It is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). ATG4C cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. It has also an activity of the delipidating enzyme for the PE-conjugated forms.